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FK506 Binding Protein 5 Shapes Stress Responsiveness: Modulation of Neuroendocrine Reactivity and Coping Behavior

Biological Psychiatry, ISSN: 0006-3223, Vol: 70, Issue: 10, Page: 928-936
2011
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Article Description

The Hsp90 cochaperone FK506 binding protein 5 (FKBP5) is an established regulator of the glucocorticoid receptor (GR), and numerous genetic studies have linked it to stress-related diseases such as major depression or posttraumatic stress disorder. However, translational studies including genetic animal models are lacking.

Bibliographic Details

Touma, Chadi; Gassen, Nils Christian; Herrmann, Leonie; Cheung-Flynn, Joyce; Büll, Dominik R; Ionescu, Irina A; Heinzmann, Jan-Michael; Knapman, Alana; Siebertz, Anna; Depping, Anna-Mareike; Hartmann, Jakob; Hausch, Felix; Schmidt, Mathias V; Holsboer, Florian; Ising, Marcus; Cox, Marc B; Schmidt, Ulrike; Rein, Theo

Elsevier BV

Neuroscience

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