Three-dimensional ordered DNA network constructed by a biomarker pair for accurate monitoring of colorectal cancer
Biosensors and Bioelectronics, ISSN: 0956-5663, Vol: 232, Page: 115335
2023
- 5Citations
- 13Captures
- 1Mentions
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Most Recent News
Investigators from Jiangsu University Report New Data on Colon Cancer (Three-dimensional Ordered Dna Network Constructed By a Biomarker Pair for Accurate Monitoring of Colorectal Cancer)
2023 JUL 13 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Daily -- New research on Oncology - Colon Cancer is the subject
Article Description
Precise and early screening of colorectal cancer (CRC) is one crucial yet challenging task for its treatment, and the analysis of multi-targets of CRC in a single assay with high accuracy is essential for pathological research and clinical diagnosis. Here, a CRC-related biomarker pair, microRNA-211 (miRNA-211) and H 2 S, was detected by constructing a three-dimensional (3D) ordered DNA network. First, trace amount of miRNA-211 could initiate a hybridization chain reaction-based amplification process. A highly ordered 3D DNA network was formed based on the organized assembly of DNA-cube frameworks that were constructed by DNA origamis and Ag nanoparticles (NPs) encapsulated inside. In the presence of the H 2 S, Ag NPs within the network can be etched to generate Ag 2 S quantum dots, which could be better visualized in fluorescence in situ cell imaging. Using the 3D DNA ordered network as the sensing platform, it can acquire dual analysis of biomolecule (miRNA-211) and inorganic gas (H 2 S) in vitro, overcoming the limitations of single type of biomarker detection in a single assay. This assay achieved a wide linearity range of H 2 S from 0.05 to 10 μM, and exhibited a low limit of detection of 4.78 nM. This strategy allows us to acquire the spatial distributions of H 2 S and miRNA expression levels in living CRC cells simultaneously, providing a highly sensitive and selective tool for early screening and monitoring of CRC.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0956566323002774; http://dx.doi.org/10.1016/j.bios.2023.115335; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85152963366&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/37087986; https://linkinghub.elsevier.com/retrieve/pii/S0956566323002774; https://dx.doi.org/10.1016/j.bios.2023.115335
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know