Multiplexed neurochemical sensing with sub-nM sensitivity across 2.25 mm 2 area
Biosensors and Bioelectronics, ISSN: 0956-5663, Vol: 261, Page: 116474
2024
- 5Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Captures5
- Readers5
Article Description
Multichannel arrays capable of real-time sensing of neuromodulators in the brain are crucial for gaining insights into new aspects of neural communication. However, measuring neurochemicals, such as dopamine, at low concentrations over large areas has proven challenging. In this research, we demonstrate a novel approach that leverages the scalability and processing power offered by microelectrode array devices integrated with a functionalized, high-density microwire bundle, enabling electrochemical sensing at an unprecedented scale and spatial resolution. The sensors demonstrate outstanding selective molecular recognition by incorporating a selective polymeric membrane. By combining cutting-edge commercial multiplexing, digitization, and data acquisition hardware with a bio-compatible and highly sensitive neurochemical interface array, we establish a powerful platform for neurochemical analysis. This multichannel array has been successfully utilized in vitro and ex vivo systems. Notably, our results show a sensing area of 2.25 mm 2 with an impressive detection limit of 820 pM for dopamine. This new approach paves the way for investigating complex neurochemical processes and holds promise for advancing our understanding of brain function and neurological disorders.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0956566324004792; http://dx.doi.org/10.1016/j.bios.2024.116474; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85195611053&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/38870827; https://linkinghub.elsevier.com/retrieve/pii/S0956566324004792; https://dx.doi.org/10.1016/j.bios.2024.116474
Elsevier BV
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