Natural compounds and pharmaceuticals reprogram leukemia cell differentiation pathways
Biotechnology Advances, ISSN: 0734-9750, Vol: 33, Issue: 6, Page: 785-797
2015
- 34Citations
- 51Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations34
- Citation Indexes34
- 34
- CrossRef31
- Captures51
- Readers51
- 51
Review Description
In addition to apoptosis resistance and cell proliferation capacities, the undifferentiated state also characterizes most cancer cells, especially leukemia cells. Cell differentiation is a multifaceted process that depends on complex regulatory networks that involve transcriptional, post-transcriptional and epigenetic regulation of gene expression. The time- and spatially-dependent expression of lineage-specific genes and genes that control cell growth and cell death is implicated in the process of maturation. The induction of cancer cell differentiation is considered an alternative approach to elicit cell death and proliferation arrest. Differentiation therapy has mainly been developed to treat acute myeloid leukemia, notably with all-trans retinoic acid (ATRA). Numerous molecules from diverse natural or synthetic origins are effective alone or in association with ATRA in both in vitro and in vivo experiments. During the last two decades, pharmaceuticals and natural compounds with various chemical structures, including alkaloids, flavonoids and polyphenols, were identified as potential differentiating agents of hematopoietic pathways and osteogenesis.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0734975015000646; http://dx.doi.org/10.1016/j.biotechadv.2015.03.013; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84939260659&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/25886879; https://linkinghub.elsevier.com/retrieve/pii/S0734975015000646; https://dx.doi.org/10.1016/j.biotechadv.2015.03.013
Elsevier BV
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