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Transkarbams with terminal branching as transdermal permeation enhancers

Bioorganic & Medicinal Chemistry Letters, ISSN: 0960-894X, Vol: 18, Issue: 5, Page: 1712-1715
2008
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Article Description

Transkarbams (T) represent novel group of highly active, non-toxic transdermal permeation enhancers. This study was focused on the influence of small symmetrical terminal branching on their enhancing activity. Series of T with terminal methyl or ethyl branching was prepared and their permeation-enhancing activity was compared to that of their linear analogues. The results showed completely a different behaviour from similarly branched alcohols, supporting the key role of the ammonium-carbamate polar head in the enhancing activity of T.

Bibliographic Details

Klimentová, Jana; Kosák, Petr; Vávrová, Katerina; Holas, Tomás; Novotný, Jakub; Hrabálek, Alexandr

Elsevier BV

Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Chemistry

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