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Allobetulin derived seco -oleananedicarboxylates act as inhibitors of acetylcholinesterase

Bioorganic & Medicinal Chemistry Letters, ISSN: 0960-894X, Vol: 25, Issue: 13, Page: 2654-2656
2015
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Ring opening of allobetulone gave either seco -acid 8 or di-acid 4. These acids were converted into esters that were screened by Ellman’s assay. A dibutenylester of low cytotoxicity (NIH 3T3 murine embryonic fibroblasts) was shown to be a good mixed-type inhibitor ( K i = 3.39, K i ′ = 2.26 μM) for acetylcholinesterase.

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