1 H -1,2,3-Triazolyl-substituted 1,3,4-oxadiazole derivatives containing structural features of ibuprofen/naproxen: Their synthesis and antibacterial evaluation
Bioorganic & Medicinal Chemistry Letters, ISSN: 0960-894X, Vol: 26, Issue: 21, Page: 5212-5217
2016
- 43Citations
- 56Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations43
- Citation Indexes43
- 43
- CrossRef34
- Captures56
- Readers56
- 56
Article Description
1 H -1,2,3-Triazolyl-substituted 1,3,4-oxadiazole derivatives containing structural features of ibuprofen/naproxen were synthesized for the first time using a Cu catalyzed azide–alkyne cycloaddition (CuAAC) strategy. An optimized reaction condition was established for this purpose and twenty new compounds were synthesized using this methodology. Several of these compounds showed good to reasonable antibacterial activities when tested against three gram-positive and three gram-negative species. The compound 4m i.e. N -(2-chlorophenyl)-2-(4-((5-(1-(6-methoxynaphthalen-2-yl)ethyl)-1,3,4-oxadiazol-2-ylthio)methyl)-1 H -1,2,3-triazol-1-yl)acetamide showed promising activities across both the species.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0960894X16310083; http://dx.doi.org/10.1016/j.bmcl.2016.09.059; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84992200631&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/27727124; https://linkinghub.elsevier.com/retrieve/pii/S0960894X16310083; https://dx.doi.org/10.1016/j.bmcl.2016.09.059
Elsevier BV
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