Endosomal localization of FIP3/Arfophilin-1 and its involvement in dendritic formation of mouse hippocampal neurons
Brain Research, ISSN: 0006-8993, Vol: 1557, Page: 55-65
2014
- 10Citations
- 20Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations10
- Citation Indexes10
- 10
- CrossRef6
- Captures20
- Readers20
- 20
Article Description
Endosomal trafficking mediated by Rab11 and Arf6 small GTPases is essential for various neuronal functions. Family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1, also termed Eferin, is a dual effector for Rab11 and Arf6 and implicated in endosomal trafficking during cytokinesis. To understand the neuronal functions of FIP3, we first showed the widespread neuronal expression of FIP3 mRNA in adult mouse brain by in situ hybridization. Immunohistochemical analysis showed the association of FIP3 with a subpopulation of endosomes labeled with EEA1 and syntaxin 12 in hippocampal neurons. Immunoblot analysis showed the progressive increase of FIP3 with a peak around postnatal day 15 during hippocampal development. Furthermore, knockdown of endogenous FIP3 decreased the total dendritic length of cultured hippocampal neurons with a concomitant increase in the number of short (<40 μm) primary dendrites. Together, FIP3 is suggested to regulate dendritic formation possibly through Rab11- and Arf6-mediated endosomal trafficking.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006899314002121; http://dx.doi.org/10.1016/j.brainres.2014.02.018; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84896547646&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/24576489; https://linkinghub.elsevier.com/retrieve/pii/S0006899314002121; https://dx.doi.org/10.1016/j.brainres.2014.02.018
Elsevier BV
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