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Humanized NOD-SCID IL2rg –/– mice as a preclinical model for cancer research and its potential use for individualized cancer therapies

Cancer Letters, ISSN: 0304-3835, Vol: 344, Issue: 1, Page: 13-19
2014
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Article Description

Humanized mouse models have been developed and utilized in cancer research for decades. Newly developed combined immunodeficient NOD-SCID-IL2rg –/– mice are more permissive for human cells and tissue engraftment. In this review, we discuss the use of NOD-SCID-IL2rg –/– mice as a preclinical tool in cancer research and its potential use for individualized cancer therapies.

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