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Upregulating the Heme Oxygenase System Suppresses Left Ventricular Hypertrophy in Adult Spontaneously Hypertensive Rats for 3 Months

Journal of Cardiac Failure, ISSN: 1071-9164, Vol: 15, Issue: 7, Page: 616-628
2009
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Article Description

Aldosterone and phospholipase C (PLC) stimulate nuclear factor-kappaB (NF-κB) and activating-protein (AP-1), causing fibrosis and hypertrophy. Besides harboring binding sites for NF-κB and AP-1, heme oxygenase (HO-1) generates cytoprotective products, including bilirubin and ferritin. The multifaceted interaction between HO-1 and aldosterone-PLC profibrotic axis in cardiac hypertrophy of spontaneously hypertensive rats (SHR) was studied.

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