Missense Genetic Variation of ICAM1 and Incident Heart Failure
Journal of Cardiac Failure, ISSN: 1071-9164, Vol: 29, Issue: 8, Page: 1163-1172
2023
- 8Citations
- 2Captures
- 1Mentions
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Metrics Details
- Citations8
- Citation Indexes8
- CrossRef5
- Captures2
- Readers2
- Mentions1
- News Mentions1
- News1
Most Recent News
Researchers from Northwestern University Describe Findings in Heart Failure (Missense Genetic Variation of Icam1 and Incident Heart Failure)
2023 OCT 05 (NewsRx) -- By a News Reporter-Staff News Editor at Disease Prevention Daily -- New research on Heart Disorders and Diseases - Heart
Article Description
Intercellular adhesion molecule-1 (ICAM-1) is a cell surface protein that participates in endothelial activation and is hypothesized to play a central role in heart failure (HF). We evaluated associations of ICAM1 missense genetic variants with circulating ICAM-1 levels and with incident HF. We identified 3 missense variants within ICAM1 (rs5491, rs5498 and rs1799969) and evaluated their associations with ICAM-1 levels in the Coronary Artery Risk Development in Young Adults Study and the Multi-Ethnic Study of Atherosclerosis (MESA). We determined the association among these 3 variants and incident HF in MESA. We separately evaluated significant associations in the Atherosclerosis Risk in Communities (ARIC) study. Of the 3 missense variants, rs5491 was common in Black participants (minor allele frequency [MAF] > 20%) and rare in other race/ethnic groups (MAF < 5%). In Black participants, the presence of rs5491 was associated with higher levels of circulating ICAM-1 at 2 timepoints separated by 8 years. Among Black participants in MESA (n = 1600), the presence of rs5491 was associated with an increased risk of incident HF with preserved ejection fraction (HFpEF; HR = 2.30; [95% CI 1.25–4.21; P = 0.007]). The other ICAM1 missense variants (rs5498 and rs1799969) were associated with ICAM-1 levels, but there were no associations with HF. In ARIC, rs5491 was significantly associated with incident HF (HR = 1.24 [95% CI 1.02 – 1.51]; P = 0.03), with a similar direction of effect for HFpEF that was not statistically significant. A common ICAM1 missense variant among Black individuals may be associated with increased risk of HF, which may be HFpEF-specific.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1071916423000428; http://dx.doi.org/10.1016/j.cardfail.2023.02.003; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85151412455&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/36882149; https://linkinghub.elsevier.com/retrieve/pii/S1071916423000428; https://dx.doi.org/10.1016/j.cardfail.2023.02.003
Elsevier BV
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