Intracellular GSH levels rather than ROS levels are tightly related to AMA-induced HeLa cell death
Chemico-Biological Interactions, ISSN: 0009-2797, Vol: 171, Issue: 1, Page: 67-78
2008
- 31Citations
- 27Captures
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Metrics Details
- Citations31
- Citation Indexes31
- 31
- CrossRef19
- Captures27
- Readers27
- 27
Article Description
Antimycin A (AMA) inhibits succinate oxidase and NADH oxidase, and also inhibits mitochondrial electron transport between cytochromes b and c. We investigated the involvement of ROS and GSH in AMA-induced HeLa cell death. AMA increased the intracellular H 2 O 2 and O 2 − levels and reduced the intracellular GSH content. ROS scavengers (Tempol, Tiron, Trimetazidine and NAC) did not down-regulate the production of ROS and inhibit apoptosis in AMA-treated cells. Treatment with NAC and N -propylgallate showing the enhancement of GSH depletion in AMA-treated cells significantly intensified the levels of apoptosis. Calpain inhibitors I and II (calpain inhibitor III) and Ca 2+ -chelating agent (EGTA/AM) significantly reduced H 2 O 2 levels in AMA-treated HeLa cells. However, treatment with calpain inhibitor III intensified the levels of O 2 − in AMA-treated cells. In addition, calpain inhibitor III strongly depleted GSH content with an enhancement of apoptosis in AMA-treated cells. Conclusively, the changes of ROS by AMA were not tightly correlated with apoptosis in HeLa cells. However, intracellular GSH levels are tightly related to AMA-induced cell death.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0009279707002761; http://dx.doi.org/10.1016/j.cbi.2007.08.011; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=36749097369&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/17935707; https://linkinghub.elsevier.com/retrieve/pii/S0009279707002761; https://dx.doi.org/10.1016/j.cbi.2007.08.011
Elsevier BV
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