Insights into the enzymatic formation, chemical features, and biological role of the flavin-N5-oxide
Current Opinion in Chemical Biology, ISSN: 1367-5931, Vol: 47, Page: 47-53
2018
- 12Citations
- 25Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations12
- Citation Indexes12
- CrossRef12
- 12
- Captures25
- Readers25
- 25
Review Description
Flavoenzymes are versatile catalysts that mostly facilitate redox reactions such as the oxygenation of organic substrates. Commonly, flavin monooxygenases employ a flavin-C4a-(hydro)peroxide as oxygenating species. Recently, however, a modified N5-functionalized flavin cofactor featuring a distinct nitrone moiety — the flavin-N5-oxide — was reported for the first time as oxygenating species in the bacterial enzyme EncM that catalyzes the dual oxidation of a reactive poly-β-ketone substrate. Meanwhile, additional flavoenzymes have been reported that form the flavin-N5-oxide. Here, we highlight aspects of the discovery and characterization of this novel flavin redox state with a focus on recent findings that shed more light onto its chemical features and enzymatic formation. We furthermore provide a rationale for the oxygenase functionality of EncM by contrast with structurally related flavin oxidases and dehydrogenases from the vanillyl alcohol oxidase/p-cresol methylhydroxylase flavoprotein (VAO/PCMH) superfamily. In addition, the possible biological roles of the flavin-N5-oxide are discussed.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1367593118300607; http://dx.doi.org/10.1016/j.cbpa.2018.08.003; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85052216383&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/30165331; https://linkinghub.elsevier.com/retrieve/pii/S1367593118300607; https://dx.doi.org/10.1016/j.cbpa.2018.08.003
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know