Recent advances in the structural biology of modular polyketide synthases and nonribosomal peptide synthetases
Current Opinion in Chemical Biology, ISSN: 1367-5931, Vol: 71, Page: 102223
2022
- 8Citations
- 17Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations8
- Citation Indexes8
- Captures17
- Readers17
- 17
Review Description
Polyketides and nonribosomal peptides are an important class of natural products with useful bioactivities. These compounds are similarly biosynthesized using enzymes with modular structures despite having different physicochemical properties. These enzymes are attractive targets for bioengineering to produce “unnatural” natural products owing to their modular structures. Therefore, their structures have been studied for a long time; however, the main focus was on truncated-single domains. Surprisingly, there is an increasing number of the structures of whole modules reported, most of which have been enabled through the recent advances in cryogenic electron microscopy technology. In this review, we have summarized the recent advances in the structural elucidation of whole modules.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1367593122001089; http://dx.doi.org/10.1016/j.cbpa.2022.102223; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85139828910&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/36265331; https://linkinghub.elsevier.com/retrieve/pii/S1367593122001089; https://dx.doi.org/10.1016/j.cbpa.2022.102223
Elsevier BV
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