Adipocyte fatty acid-binding protein: An important gene related to lipid metabolism in chicken adipocytes
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, ISSN: 1096-4959, Vol: 157, Issue: 4, Page: 357-363
2010
- 22Citations
- 18Captures
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Metrics Details
- Citations22
- Citation Indexes22
- 22
- CrossRef19
- Captures18
- Readers18
- 18
Article Description
Fatty acid-binding proteins (FABPs) may facilitate the diffusion of fatty acids within the cytoplasm. Adipocyte FABP (A-FABP) null mice exhibit altered rates of lipolysis, and reprogrammed expression of genes related to lipid metabolism. In the current study, chicken adipocytes with short hairpin RNA-mediated knockdown and cDNA overexpression of A-FABP were used to investigate the role of chicken A-FABP in lipid metabolism of adipocytes. The results showed that there was no significant change of lipid metabolism in the A-FABP interference adipocytes. However, in the A-FABP overexpression adipocytes, the lipolysis was increased significantly at 36 h ( p < 0.05), and lipid accumulation was increased significantly at 48, 60 and 72 h ( p < 0.05). The expression of PPAR γ and perilipin genes were upregulated, while the expression of E-FABP gene was downregulated after transfection with pcDNA3.1/A-FABP ( p < 0.05). The present study suggested that A-FABP gene might affect the lipid metabolism through the PPAR γ pathway, and the function between A-FABP and E-FABP gene was compensatory in the chickens.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1096495910002046; http://dx.doi.org/10.1016/j.cbpb.2010.08.005; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77957925869&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/20728564; https://linkinghub.elsevier.com/retrieve/pii/S1096495910002046; https://dx.doi.org/10.1016/j.cbpb.2010.08.005
Elsevier BV
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