Tannin alleviates glyphosate exposure-induced apoptosis, necrosis and immune dysfunction in hepatic L8824 cell line by inhibiting ROS/PTEN/PI3K/AKT pathway
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, ISSN: 1532-0456, Vol: 266, Page: 109551
2023
- 7Citations
- 14Captures
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Article Description
Glyphosate can cause tissue damage such as liver and kidney in mammals. Tannin has anti-inflammatory, antibacterial and anti-inflammatory properties. However, the effect of glyphosate on the growth of L8824 cell line and the effect of tannin on antagonism of glyphosate through the ROS/PTEN/PI3K/AKT axis are unclear. In this study, L8824 cells were treated with glyphosate (50 μg/mL) and/or tannin (4.5 μM) for 24 h to establish a model. The results showed that glyphosate exposure increased ROS and MDA levels, decreased CAT and SOD activities. PTEN was activated and the PI3K/AKT signaling pathway was inhibited. The P53/Bcl-2/Bax/CytC/Caspase3 and RIPK1/RIPK3/MLKL pathways were also activated. In addition, the cytokines and antimicrobial peptides LEAP-2, TNF-α and IL-1β were increased while β-defensin, Hepcidin, IL-2 and IFN-γ were decreased. The use of tannin reduced the adverse effects of glyphosate exposure on L8824 cells significantly. In conclusion, tannin can trigger oxidative stress via PTEN/PI3K/AKT pathway to cause apoptosis, necroptosis and immune dysfunction of L8824 cells.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1532045623000066; http://dx.doi.org/10.1016/j.cbpc.2023.109551; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85147122637&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/36681169; https://linkinghub.elsevier.com/retrieve/pii/S1532045623000066; https://dx.doi.org/10.1016/j.cbpc.2023.109551
Elsevier BV
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