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Sports doping: Emerging designer and therapeutic β 2 -agonists

Clinica Chimica Acta, ISSN: 0009-8981, Vol: 425, Page: 242-258
2013
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Review Description

Beta 2 -adrenergic agonists, or β 2 -agonists, are considered essential bronchodilator drugs in the treatment of bronchial asthma, both as symptom-relievers and, in combination with inhaled corticosteroids, as disease-controllers. The use of β 2 -agonists is prohibited in sports by the World Anti-Doping Agency (WADA) due to claimed anabolic effects, and also, is prohibited as growth promoters in cattle fattening in the European Union. This paper reviews the last seven-year (2006–2012) literature concerning the development of novel β 2 -agonists molecules either by modifying the molecule of known β 2 -agonists or by introducing moieties producing indole-, adamantyl- or phenyl urea derivatives. New emerging β 2 -agonists molecules for future therapeutic use are also presented, intending to emphasize their potential use for doping purposes or as growth promoters in the near future.

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