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Biological variation: Evaluation of methods for constructing confidence intervals for estimates of within-person biological variation for different distributions of the within-person effect

Clinica Chimica Acta, ISSN: 0009-8981, Vol: 468, Page: 166-173
2017
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Article Description

Precise estimates of the within-person biological variation, CV I, can be essential both for monitoring patients and for setting analytical performance specifications. The confidence interval, CI, may be used to evaluate the reliability of an estimate, as it is a good measure of the uncertainty of the estimated CV I. The aim of the present study is to evaluate and establish methods for constructing a CI with the correct coverage probability and non-cover probability when estimating CV I.

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