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GDF15 research from bench to bedside

Cancer Cell, ISSN: 1535-6108, Vol: 42, Issue: 11, Page: 1823-1824
2024
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Article Description

Pre-clinical data suggest that increased circulating growth differentiation factor 15 (GDF15) is a cause of both anorexia/cachexia syndromes and hyperemesis gravidarum in pregnancy, serious conditions with no highly effective treatment. A phase 2 study of a therapeutic GDF15 monoclonal antibody in the New England Journal of Medicine suggests that effective treatment of anorexia/cachexia in cancer may be approaching.

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