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Connecting COX-2 and Wnt in cancer

Cancer Cell, ISSN: 1535-6108, Vol: 9, Issue: 1, Page: 6-8
2006
  • 106
    Citations
  • 0
    Usage
  • 56
    Captures
  • 0
    Mentions
  • 17
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    106
  • Captures
    56
  • Social Media
    17
    • Shares, Likes & Comments
      17
      • Facebook
        17

Article Description

Both the cyclooxygenase-2 (COX-2) and Wnt signaling cascades are active in the majority of colorectal cancers. Nevertheless, a direct link between these two key pathways has remained elusive. Recent reports show that one of the bioactive products of COX-2, prostaglandin E2, activates components of the canonical Wnt signaling system. The findings reviewed below reveal important crosstalk between these pathways, which may provide opportunities for the development of new drugs for treatment and/or prevention of colorectal cancer.

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