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Design, synthesis and biological evaluation of 1,2,4-oxadiazole linked 1,2,4-thiadiazole-pyrimidines as anticancer agents

Chemical Data Collections, ISSN: 2405-8300, Vol: 32, Page: 100653
2021
  • 9
    Citations
  • 0
    Usage
  • 12
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    9
    • Citation Indexes
      9
  • Captures
    12

Dataset Description

A novel library of 1,2,4-oxadiazole linked 1,2,4-thiadiazole-pyrimidines ( 10a-j ) were designed and synthesized. All compounds were characterized by FTIR, NMR and high resolution Mass analysis. Further, these compounds were screened for their anticancer activity against a panel of human cancer cell lines such as MCF-7 (human breast cancer), A-549 (human non -small cell lung cancer), Colo-205 (human adenocarcinoma colon cancer) and A2780 (human ovarian cancer) by employing MTT assay. The clinical drug (etoposide) used as positive control. Among all synthesized compounds, five compounds 10b, 10c, 10d, 10i and 10j were possessed more promising anticancer activity on all cell lines.

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