Design, synthesis and biological evaluation of 1,2,4-oxadiazole linked 1,2,4-thiadiazole-pyrimidines as anticancer agents
Chemical Data Collections, ISSN: 2405-8300, Vol: 32, Page: 100653
2021
- 9Citations
- 12Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Dataset Description
A novel library of 1,2,4-oxadiazole linked 1,2,4-thiadiazole-pyrimidines ( 10a-j ) were designed and synthesized. All compounds were characterized by FTIR, NMR and high resolution Mass analysis. Further, these compounds were screened for their anticancer activity against a panel of human cancer cell lines such as MCF-7 (human breast cancer), A-549 (human non -small cell lung cancer), Colo-205 (human adenocarcinoma colon cancer) and A2780 (human ovarian cancer) by employing MTT assay. The clinical drug (etoposide) used as positive control. Among all synthesized compounds, five compounds 10b, 10c, 10d, 10i and 10j were possessed more promising anticancer activity on all cell lines.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2405830021000082; http://dx.doi.org/10.1016/j.cdc.2021.100653; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85099929194&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S2405830021000082; https://dx.doi.org/10.1016/j.cdc.2021.100653
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know