Talin: an emerging focal point of adhesion dynamics
Current Opinion in Cell Biology, ISSN: 0955-0674, Vol: 16, Issue: 1, Page: 94-98
2004
- 144Citations
- 160Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations144
- Citation Indexes144
- 144
- CrossRef132
- Captures160
- Readers160
- 160
Review Description
The adhesion protein talin and the phosphoinositide PIP2 are emerging as key modulators of adhesion dynamics. Recent genetic studies on talin demonstrate its physiological role in organizing adhesions, stabilizing integrin–actin linkages and mediating integrin signaling in vivo. Biophysical force measurements provide further evidence that it is required for the reinforcement of the extracellular matrix–integrin–actin connection. Knockdown data along with structural analyses establish a major role for talin in ‘inside-out’ integrin activation through its direct interaction with integrin cytoplasmic domains. A recently uncovered role for talin is the recruitment of a PIPKIγ isoform to adhesions. This introduces a novel connection between talin and PIP2 generation. Finally, PIP2 also stimulates the transient, direct binding interaction of the Arp2/3 complex with vinculin and thus may couple adhesion to actin assembly.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0955067403001650; http://dx.doi.org/10.1016/j.ceb.2003.11.007; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=1642341451&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/15037311; https://linkinghub.elsevier.com/retrieve/pii/S0955067403001650; https://dx.doi.org/10.1016/j.ceb.2003.11.007
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know