Control by Ca 2+ of mitochondrial structure and function in pancreatic β-cells
Cell Calcium, ISSN: 0143-4160, Vol: 91, Page: 102282
2020
- 16Citations
- 19Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations16
- Citation Indexes16
- 16
- CrossRef11
- Captures19
- Readers19
- 19
Article Description
Mitochondria play a central role in glucose metabolism and the stimulation of insulin secretion from pancreatic β-cells. In this review, we discuss firstly the regulation and roles of mitochondrial Ca 2+ transport in glucose-regulated insulin secretion, and the molecular machinery involved. Next, we discuss the evidence that mitochondrial dysfunction in β-cells is associated with type 2 diabetes, from a genetic, functional and structural point of view, and then the possibility that these changes may in part be mediated by dysregulation of cytosolic Ca 2+. Finally, we review the importance of preserved mitochondrial structure and dynamics for mitochondrial gene expression and their possible relevance to the pathogenesis of type 2 diabetes.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S014341602030124X; http://dx.doi.org/10.1016/j.ceca.2020.102282; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85091261062&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/32961506; https://linkinghub.elsevier.com/retrieve/pii/S014341602030124X; https://dx.doi.org/10.1016/j.ceca.2020.102282
Elsevier BV
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