Antibody plug-and-playable nanoparticles as a facile and versatile platform for targeted drug delivery
Chemical Engineering Journal, ISSN: 1385-8947, Vol: 470, Page: 144357
2023
- 9Citations
- 3Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
For effective drug delivery using nanoparticles, antibody can be beneficially utilized thanks to its high binding affinity to the target site. However, a conventional method to conjugate antibody to nanoparticles involves a multi-step synthetic process, which can damage the antibody’s intrinsic target-recognition nature. Herein, a facile approach is reported to construct a versatile targeted delivery platform, to which any desired antibodies are allowed to directly bind, by coating the nanoparticle surface with a functional fusion protein consisting of glutathione- S -transferase (GST) and the antibody-binding domain (ABD) called Z domain. The antibody-plugged nanoparticle exhibits high structural stability in biological environments and cell-specific targeting behaviors, significantly enhancing drug delivery efficiency both in vitro and in vivo for diverse therapeutic applications.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1385894723030887; http://dx.doi.org/10.1016/j.cej.2023.144357; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85163170306&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S1385894723030887; https://dx.doi.org/10.1016/j.cej.2023.144357
Elsevier BV
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