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Genomes on the Edge: Programmed Genome Instability in Ciliates

Cell, ISSN: 0092-8674, Vol: 152, Issue: 3, Page: 406-416
2013
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Molecular computers reading list 4

Continues after reading list 3. Benenson, Y. Biomolecular computing systems: principles, progress and potential. Nat Rev Genet 13, 455–468 (2012). https://doi.org/10.1038/nrg3197 Abstract: The task of information processing, or computation, can be performed by natural and man-made ‘devices’. Man-made computers are made from silicon chips, whereas natural ‘computers’, such as the brain, use cells a

Review Description

Ciliates are an ancient and diverse group of microbial eukaryotes that have emerged as powerful models for RNA-mediated epigenetic inheritance. They possess extensive sets of both tiny and long noncoding RNAs that, together with a suite of proteins that includes transposases, orchestrate a broad cascade of genome rearrangements during somatic nuclear development. This Review emphasizes three important themes: the remarkable role of RNA in shaping genome structure, recent discoveries that unify many deeply diverged ciliate genetic systems, and a surprising evolutionary “sign change” in the role of small RNAs between major species groups.

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