A Circadian Clock in the Blood-Brain Barrier Regulates Xenobiotic Efflux
Cell, ISSN: 0092-8674, Vol: 173, Issue: 1, Page: 130-139.e10
2018
- 151Citations
- 365Captures
- 4Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations151
- Citation Indexes151
- 151
- CrossRef114
- Captures365
- Readers365
- 364
- Mentions4
- News Mentions3
- News3
- References1
- Wikipedia1
Most Recent News
Защищающий мозг барьер обладает собственными биологическими часами и слабеет к ночи
Гемато-энцефалический барьер стоит на страже здоровья мозга словно вышибала у входа в ночной клуб, не пропуская вредные токсины и болезнетворные микробы. В то же время эта защита затрудняет лечение многих заболеваний. Но недавно исследователи установили, что для приёма лекарств нужно просто подобрать правильное время.
Article Description
Endogenous circadian rhythms are thought to modulate responses to external factors, but mechanisms that confer time-of-day differences in organismal responses to environmental insults/therapeutic treatments are poorly understood. Using a xenobiotic, we find that permeability of the Drosophila “blood”-brain barrier (BBB) is higher at night. The permeability rhythm is driven by circadian regulation of efflux and depends on a molecular clock in the perineurial glia of the BBB, although efflux transporters are restricted to subperineurial glia (SPG). We show that transmission of circadian signals across the layers requires cyclically expressed gap junctions. Specifically, during nighttime, gap junctions reduce intracellular magnesium ([Mg 2+ ]i), a positive regulator of efflux, in SPG. Consistent with lower nighttime efflux, nighttime administration of the anti-epileptic phenytoin is more effective at treating a Drosophila seizure model. These findings identify a novel mechanism of circadian regulation and have therapeutic implications for drugs targeted to the central nervous system.
Bibliographic Details
10.1016/j.cell.2018.02.017; 10.3410/f.732810687.793545844; 10.3410/f.732810687.793544925; 10.3410/f.732810687.793544753; 10.3410/f.732810687.793544531; 10.3410/f.732810687.793547561
http://www.sciencedirect.com/science/article/pii/S0092867418301612; http://dx.doi.org/10.1016/j.cell.2018.02.017; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85042945887&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/29526461; https://facultyopinions.com/prime/732810687#eval793545844; http://dx.doi.org/10.3410/f.732810687.793545844; https://linkinghub.elsevier.com/retrieve/pii/S0092867418301612; https://facultyopinions.com/prime/732810687#eval793544925; http://dx.doi.org/10.3410/f.732810687.793544925; https://facultyopinions.com/prime/732810687#eval793544753; http://dx.doi.org/10.3410/f.732810687.793544753; https://facultyopinions.com/prime/732810687#eval793544531; http://dx.doi.org/10.3410/f.732810687.793544531; https://facultyopinions.com/prime/732810687#eval793547561; http://dx.doi.org/10.3410/f.732810687.793547561; https://dx.doi.org/10.1016/j.cell.2018.02.017; https://f1000.com/prime/732810687#eval793544531; https://www.cell.com/cell/fulltext/S0092-8674%2818%2930161-2; http://www.cell.com/article/S0092867418301612/abstract; http://www.cell.com/article/S0092867418301612/fulltext; http://www.cell.com/article/S0092867418301612/pdf; https://www.cell.com/cell/abstract/S0092-8674(18)30161-2; https://f1000.com/prime/732810687#eval793547561; https://www.cell.com/cell/fulltext/S0092-8674(18)30161-2
Faculty Opinions Ltd
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know