HIF-1α regulates the expression of the non-conventional isoform of the cd5 gene in T cells under the hypoxic condition: A potential mechanism for CD5 neg/low phenotype of infiltrating cells in solid tumors
Cellular Immunology, ISSN: 0008-8749, Vol: 391, Page: 104755
2023
- 3Captures
- 1Mentions
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Captures3
- Readers3
- Mentions1
- News Mentions1
- News1
Most Recent News
Studies Conducted at Motilal Nehru National Institute of Technology Allahabad on Solid Cancer Recently Reported (Hif-1 & Alpha; Regulates the Expression of the Non-conventional Isoform of the Cd5 Gene In T Cells Under the Hypoxic Condition: a ...)
2023 SEP 18 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Daily -- Researchers detail new data in Oncology - Solid
Article Description
CD5, a T -cell receptor (TCR) negative regulator, is reduced on the surface of CD8+ lymphocytes in the tumor microenvironment (TME). Reduced surface CD5 expression (sCD5) occurs due to the preferential transcription of HERV-E derived exon E1B, i.e., a non-conventional form of the cd5 gene instead of its conventional exon E1A. A tumor employs several mechanisms to evade anti-tumor response, and hypoxia is one such mechanism that prevails in the TME and modulates the infiltrated T lymphocytes. We identified hypoxia response elements (HREs) upstream of E1B. We showed binding of HIF-1α onto these HREs and increased E1B mRNA expression in hypoxic T cells. This results in decreased sCD5 expression and increased cytoplasmic accumulation in T cells. We also validated our study in a solid tumor, i.e., colorectal cancer (CRC) patient samples. This hypoxia-driven mechanism reduces the surface CD5 expression on infiltrated T -cells in solid tumors.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0008874923000941; http://dx.doi.org/10.1016/j.cellimm.2023.104755; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85166770114&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/37544247; https://linkinghub.elsevier.com/retrieve/pii/S0008874923000941; https://dx.doi.org/10.1016/j.cellimm.2023.104755
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know