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HIF-1α regulates the expression of the non-conventional isoform of the cd5 gene in T cells under the hypoxic condition: A potential mechanism for CD5 neg/low phenotype of infiltrating cells in solid tumors

Cellular Immunology, ISSN: 0008-8749, Vol: 391, Page: 104755
2023
  • 0
    Citations
  • 0
    Usage
  • 3
    Captures
  • 1
    Mentions
  • 68
    Social Media
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Metrics Details

  • Captures
    3
  • Mentions
    1
    • News Mentions
      1
      • News
        1
  • Social Media
    68
    • Shares, Likes & Comments
      68
      • Facebook
        68

Most Recent News

Studies Conducted at Motilal Nehru National Institute of Technology Allahabad on Solid Cancer Recently Reported (Hif-1 & Alpha; Regulates the Expression of the Non-conventional Isoform of the Cd5 Gene In T Cells Under the Hypoxic Condition: a ...)

2023 SEP 18 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Daily -- Researchers detail new data in Oncology - Solid

Article Description

CD5, a T -cell receptor (TCR) negative regulator, is reduced on the surface of CD8+ lymphocytes in the tumor microenvironment (TME). Reduced surface CD5 expression (sCD5) occurs due to the preferential transcription of HERV-E derived exon E1B, i.e., a non-conventional form of the cd5 gene instead of its conventional exon E1A. A tumor employs several mechanisms to evade anti-tumor response, and hypoxia is one such mechanism that prevails in the TME and modulates the infiltrated T lymphocytes. We identified hypoxia response elements (HREs) upstream of E1B. We showed binding of HIF-1α onto these HREs and increased E1B mRNA expression in hypoxic T cells. This results in decreased sCD5 expression and increased cytoplasmic accumulation in T cells. We also validated our study in a solid tumor, i.e., colorectal cancer (CRC) patient samples. This hypoxia-driven mechanism reduces the surface CD5 expression on infiltrated T -cells in solid tumors.

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