Elevated levels of alpha-synuclein blunt cellular signal transduction downstream of Gq protein-coupled receptors
Cellular Signalling, ISSN: 0898-6568, Vol: 30, Page: 82-91
2017
- 8Citations
- 18Captures
- 1Mentions
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Metrics Details
- Citations8
- Citation Indexes8
- CrossRef5
- Captures18
- Readers18
- 18
- Mentions1
- News Mentions1
- News1
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Elevated levels of alpha-synuclein blunt cellular signal transduction downstream of Gq protein-coupled receptors.
Cell Signal. 2016 Nov 18;30:82-91. Authors: Volta M, Lavdas AA, Obergasteiger J, Überbacher C, Picard A, Pramstaller PP, Hicks AA, Corti C PubMed: 27871937 Submit Comment
Article Description
Alpha-synuclein is central to Parkinson's disease pathogenesis and pathology, however its precise functions are still unclear. It has been shown to bind both PLCβ1 and MAPKs, but how this property influences the downstream signaling of Gq protein-coupled receptors has not been elucidated. Here we show that recombinant expression of alpha-synuclein in human neuroblastoma cells enhances cellular levels of PLCβ1 but blunts its signaling pathway, preventing the agonist-dependent rise of cytoplasmic Ca 2+. In addition, overexpressing alpha-synuclein abolishes the activation of ERK1/2 upon agonist stimulation, indicating an upstream action in the signal transduction pathway.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S089865681630273X; http://dx.doi.org/10.1016/j.cellsig.2016.11.012; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84997848475&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/27871937; https://linkinghub.elsevier.com/retrieve/pii/S089865681630273X; https://dx.doi.org/10.1016/j.cellsig.2016.11.012
Elsevier BV
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