Dendrite-Specific Amplification of Weak Synaptic Input during Network Activity In Vivo
Cell Reports, ISSN: 2211-1247, Vol: 24, Issue: 13, Page: 3455-3465.e5
2018
- 17Citations
- 80Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations17
- Citation Indexes17
- CrossRef17
- 14
- Captures80
- Readers80
- 80
Article Description
Excitatory synaptic input reaches the soma of a cortical excitatory pyramidal neuron via anatomically segregated apical and basal dendrites. In vivo, dendritic inputs are integrated during depolarized network activity, but how network activity affects apical and basal inputs is not understood. Using subcellular two-photon stimulation of Channelrhodopsin2-expressing layer 2/3 pyramidal neurons in somatosensory cortex, nucleus-specific thalamic optogenetic stimulation, and paired recordings, we show that slow, depolarized network activity amplifies small-amplitude synaptic inputs targeted to basal dendrites but reduces the amplitude of all inputs from apical dendrites and the cell soma. Intracellular pharmacology and mathematical modeling suggests that the amplification of weak basal inputs is mediated by postsynaptic voltage-gated channels. Thus, network activity dynamically reconfigures the relative somatic contribution of apical and basal inputs and could act to enhance the detectability of weak synaptic inputs.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2211124718314074; http://dx.doi.org/10.1016/j.celrep.2018.08.088; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85053671433&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/30257207; https://linkinghub.elsevier.com/retrieve/pii/S2211124718314074; https://dx.doi.org/10.1016/j.celrep.2018.08.088
Elsevier BV
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