Synapse-to-Nucleus Communication through NFAT Is Mediated by L-type Ca 2+ Channel Ca 2+ Spike Propagation to the Soma
Cell Reports, ISSN: 2211-1247, Vol: 26, Issue: 13, Page: 3537-3550.e4
2019
- 50Citations
- 91Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations50
- Citation Indexes50
- 50
- CrossRef17
- Captures91
- Readers91
- 91
Article Description
Long-term information storage in the brain requires continual modification of the neuronal transcriptome. Synaptic inputs located hundreds of micrometers from the nucleus can regulate gene transcription, requiring high-fidelity, long-range signaling from synapses in dendrites to the nucleus in the cell soma. Here, we describe a synapse-to-nucleus signaling mechanism for the activity-dependent transcription factor NFAT. NMDA receptors activated on distal dendrites were found to initiate L-type Ca 2+ channel (LTCC) spikes that quickly propagated the length of the dendrite to the soma. Surprisingly, LTCC propagation did not require voltage-gated Na + channels or back-propagating action potentials. NFAT nuclear recruitment and transcriptional activation only occurred when LTCC spikes invaded the somatic compartment, and the degree of NFAT activation correlated with the number of somatic LTCC Ca 2+ spikes. Together, these data support a model for synapse to nucleus communication where NFAT integrates somatic LTCC Ca 2+ spikes to alter transcription during periods of heightened neuronal activity.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2211124719303122; http://dx.doi.org/10.1016/j.celrep.2019.03.005; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85063038472&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/30917310; https://linkinghub.elsevier.com/retrieve/pii/S2211124719303122; https://dx.doi.org/10.1016/j.celrep.2019.03.005
Elsevier BV
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