Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target
Cell Reports, ISSN: 2211-1247, Vol: 39, Issue: 11, Page: 110923
2022
- 12Citations
- 48Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations12
- Citation Indexes11
- 11
- CrossRef10
- Patent Family Citations1
- Patent Families1
- Captures48
- Readers48
- 48
- Mentions1
- References1
- Wikipedia1
Article Description
The uptake and digestion of host hemoglobin by malaria parasites during blood-stage growth leads to significant oxidative damage of membrane lipids. Repair of lipid peroxidation damage is crucial for parasite survival. Here, we demonstrate that Plasmodium falciparum imports a host antioxidant enzyme, peroxiredoxin 6 (PRDX6), during hemoglobin uptake from the red blood cell cytosol. PRDX6 is a lipid-peroxidation repair enzyme with phospholipase A 2 (PLA 2 ) activity. Inhibition of PRDX6 with a PLA 2 inhibitor, Darapladib, increases lipid-peroxidation damage in the parasite and disrupts transport of hemoglobin-containing vesicles to the food vacuole, causing parasite death. Furthermore, inhibition of PRDX6 synergistically reduces the survival of artemisinin-resistant parasites following co-treatment of parasite cultures with artemisinin and Darapladib. Thus, PRDX6 is a host-derived drug target for development of antimalarial drugs that could help overcome artemisinin resistance.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2211124722007008; http://dx.doi.org/10.1016/j.celrep.2022.110923; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85131969333&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/35705035; https://linkinghub.elsevier.com/retrieve/pii/S2211124722007008; https://dx.doi.org/10.1016/j.celrep.2022.110923
Elsevier BV
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