MDA-LDL vaccination induces athero-protective germinal-center-derived antibody responses
Cell Reports, ISSN: 2211-1247, Vol: 41, Issue: 2, Page: 111468
2022
- 13Citations
- 24Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations13
- Citation Indexes13
- 13
- CrossRef5
- Captures24
- Readers24
- 24
Article Description
Atherosclerosis is a chronic inflammatory disease of the arteries that can lead to thrombosis, infarction, and stroke and is the leading cause of mortality worldwide. Immunization of pro-atherogenic mice with malondialdehyde-modified low-density lipoprotein (MDA-LDL) neo-antigen is athero-protective. However, the immune response to MDA-LDL and the mechanisms responsible for this athero-protection are not completely understood. Here, we find that immunization of mice with MDA-LDL elicits memory B cells, plasma cells, and switched anti-MDA-LDL antibodies as well as clonal expansion and affinity maturation, indicating that MDA-LDL triggers a bona fide germinal center antibody response. Further, Prdm1 fl/fl Aicda -Cre +/ki Ldlr −/− pro-atherogenic chimeras, which lack germinal center-derived plasma cells, show accelerated atherosclerosis. Finally, we show that MDA-LDL immunization is not athero-protective in mice lacking germinal-center-derived plasma cells. Our findings give further support to the development of MDA-LDL-based vaccines for the prevention or treatment of atherosclerosis.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2211124722013183; http://dx.doi.org/10.1016/j.celrep.2022.111468; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85139722381&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/36223741; https://linkinghub.elsevier.com/retrieve/pii/S2211124722013183; https://dx.doi.org/10.1016/j.celrep.2022.111468
Elsevier BV
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