IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection
Cell Host & Microbe, ISSN: 1931-3128, Vol: 9, Issue: 5, Page: 363-375
2011
- 591Citations
- 400Captures
- 4Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations591
- Citation Indexes590
- 590
- CrossRef542
- Patent Family Citations1
- 1
- Captures400
- Readers400
- 400
- Mentions4
- Blog Mentions3
- Blog3
- News Mentions1
- 1
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Toosendanin activates caspase-1 and induces maturation of IL-1β to inhibit type 2 porcine reproductive and respiratory syndrome virus replication via an IFI16-dependent pathway
Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) is a prevalent and endemic swine pathogen which causes significant economic losses in the global swine industry.
Article Description
Inflammasomes are cytoplasmic sensors of foreign molecules, including pathogens, and function to induce caspase-1 activation and IL-1β cytokine maturation. Whether such a mechanism exists in the nucleus and is effective against nuclear replicating pathogens is unknown. Nuclear replicating herpesvirus KSHV is associated with Kaposi Sarcoma, an angioproliferative tumor characterized by an inflammatory microenvironment including IL-1β. We demonstrate that during KSHV infection of endothelial cells, interferon gamma-inducible protein 16 (IFI16) interacts with the adaptor molecule ASC and procaspase-1 to form a functional inflammasome. This complex was initially detected in the nucleus and subsequently in the perinuclear area. KSHV gene expression and/or latent KSHV genome is required for inflammasome activation and IFI16 colocalizes with the KSHV genome in the infected cell nucleus. Caspase-1 activation by KSHV was reduced by IFI16 and ASC silencing. Our studies reveal IFI16 as a nuclear pathogen sensor and demonstrate that the inflammasome also functions in the nucleus.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1931312811001302; http://dx.doi.org/10.1016/j.chom.2011.04.008; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79956061094&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/21575908; https://facultyopinions.com/prime/11385956#eval12400054; http://dx.doi.org/10.3410/f.11385956.12400054; https://linkinghub.elsevier.com/retrieve/pii/S1931312811001302; http://www.cell.com/cell-host-microbe/abstract/S1931-3128(11)00130-2?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1931312811001302%3Fshowall%3Dtrue; http://www.cell.com/article/S1931312811001302/abstract; http://www.cell.com/article/S1931312811001302/fulltext; http://www.cell.com/article/S1931312811001302/pdf; http://f1000.com/11385956#eval12400054; http://linkinghub.elsevier.com/retrieve/pii/S1931312811001302
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