+Facile extraction of azide in sartan drugs using magnetized anion-exchange metal-organic frameworks prior to ion chromatography

Quaternary amine functionalized metal-organic framework MIL-101(Cr) (MIL-101(Cr)-NMe 3 ) was prepared as the sorbent for the magnetic solid-phase extraction (MSPE) of azide from sartan drugs before ion chromatography determination. Magnetization of MIL-101-NMe 3 were achieved concurrently by adding MIL-101-NMe 3 and Fe 3 O 4 @SiO 2 to the sample solution under ultrasonication. The prepared Fe 3 O 4 @SiO 2 /MIL-101-NMe 3 gave the adsorption capacity of 37.5 mg g −1. The developed method had a detection limit of 0.24 μg L −1 and quantitation limit of 0.79 μg L −1 for azide. The relative standard deviations for the intra-day retention time and peak area were 0.52% and 0.36% (n = 5), respectively. The developed method was successfully applied for the determination of azide in sartan drugs with the recoveries from 96.5% to 100.5%.