Simultaneous enantio- and diastereo-selective high-performance liquid chromatography separation of paroxetine on an immobilized amylose-based chiral stationary phase under green reversed-phase conditions
Journal of Chromatography A, ISSN: 0021-9673, Vol: 1653, Page: 462406
2021
- 9Citations
- 5Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations9
- Citation Indexes9
- CrossRef4
- Captures5
- Readers5
Article Description
A simple and green high-performance liquid chromatography method for the separation of paroxetine from its enantiomeric and diastereomeric impurities has been developed. The simultaneous chromatographic resolution was carried out on the amylose-based Chiralpak IA-3 chiral stationary phase using the mixture ethanol-water-diethylamine 80:20:0.1 (v/v/v) as a mobile phase. The effects of substitution of ethanol with methanol or acetonitrile and changes in column temperature on selectivity have been carefully investigated. The optimized single-run HPLC protocol allows the baseline separation of the enantiomers of paroxetine without suffering from interference from five other chiral and achiral impurities reported in the monograph of the European Pharmacopoeia.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0021967321005306; http://dx.doi.org/10.1016/j.chroma.2021.462406; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85111020707&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/34320436; https://linkinghub.elsevier.com/retrieve/pii/S0021967321005306; https://dx.doi.org/10.1016/j.chroma.2021.462406
Elsevier BV
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