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High Expression of Class III β-Tubulin Predicts Good Response to Neoadjuvant Taxane and Doxorubicin/Cyclophosphamide-Based Chemotherapy in Estrogen Receptor–Negative Breast Cancer

Clinical Breast Cancer, ISSN: 1526-8209, Vol: 13, Issue: 2, Page: 103-108
2013
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Article Description

Expression of class ΙΙΙ β−tubulin (βΙΙΙ-tubulin) correlates with tumor progression and resistance to taxane-based therapies for several human malignancies including breast cancer. However its predictive value in a neoadjuvant setting in breast cancer remains unexplored. The objective of this explorative study was to determine whether βΙΙΙ-tubulin expression in breast cancer correlated with pathologic characteristics and whether its expression was predictive of response to neoadjuvant chemotherapy. We determined βΙΙΙ-tubulin expression in 85 breast cancers, including 41 localized breast cancers treated with primary surgery and 44 treated with neoadjuvant chemotherapy before surgery. βΙΙΙ-tubulin expression was evaluated by immunohistochemical methods and was correlated with pathologic characteristics and response to neoadjuvant chemotherapy using residual cancer burden (RCB) score. High βΙΙΙ-tubulin expression was significantly associated with poorly differentiated high-grade breast cancers ( P =.003) but not with tumor size, estrogen receptor (ER) status, or human epidermal growth factor receptor 2 (HER2)/ neu overexpression. In ER – tumors treated with neoadjuvant chemotherapy, high βΙΙΙ-tubulin expression was associated with a significantly greater likelihood of achieving a good pathologic response to chemotherapy as reflected by lower RCB scores ( P =.021). This study reveals differential βΙΙΙ-tubulin expression in breast cancers of different histologic grades, hormone receptors, and HER2/ neu status. It also suggests a potential role for βΙΙΙ-tubulin as a predictive biomarker for response in neoadjuvant chemotherapy for ER – breast cancer, which has not been previously reported. These data provide a strong rationale for considering βΙΙΙ-tubulin status and further validation of this marker in a large study.

Bibliographic Details

http://www.sciencedirect.com/science/article/pii/S1526820912002595; http://dx.doi.org/10.1016/j.clbc.2012.11.003; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84875182273&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/23218766; https://linkinghub.elsevier.com/retrieve/pii/S1526820912002595; http://www.clinical-breast-cancer.com/article/S1526-8209(12)00259-5/abstract; http://www.clinical-breast-cancer.com/retrieve/pii/S1526820912002595; https://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=http%3A%2F%2Fwww.clinical-breast-cancer.com%2Fretrieve%2Fpii%2FS1526820912002595&rc=0&code=clbc-site; http://acw.elsevier.com/SSOCore?return=https%3A%2F%2Fsecure.jbs.elsevierhealth.com%2Faction%2FconsumeSsoCookie%3FredirectUri%3Dhttp%253A%252F%252Fwww.clinical-breast-cancer.com%252Faction%252FconsumeSharedSessionAction%253FJSESSIONID%253Daaaeo0a_7TVZL7KalLTxv%2526MAID%253DoY7Rt8lkEWets8qLPzV%25252FWw%25253D%25253D%2526SERVER%253DWZ6myaEXBLGliB%25252BRW%25252F74SA%25253D%25253D%2526ORIGIN%253D941239582%2526RD%253DRD; http://acw.elsevier.com/SSOCore/?return=https%3A%2F%2Fsecure.jbs.elsevierhealth.com%2Faction%2FconsumeSsoCookie%3FredirectUri%3Dhttp%253A%252F%252Fwww.clinical-breast-cancer.com%252Faction%252FconsumeSharedSessionAction%253FJSESSIONID%253Daaaeo0a_7TVZL7KalLTxv%2526MAID%253DoY7Rt8lkEWets8qLPzV%25252FWw%25253D%25253D%2526SERVER%253DWZ6myaEXBLGliB%25252BRW%25252F74SA%25253D%25253D%2526ORIGIN%253D941239582%2526RD%253DRD; https://secure.jbs.elsevierhealth.com/action/consumeSsoCookie?redirectUri=http%3A%2F%2Fwww.clinical-breast-cancer.com%2Faction%2FconsumeSharedSessionAction%3FJSESSIONID%3Daaaeo0a_7TVZL7KalLTxv%26MAID%3DoY7Rt8lkEWets8qLPzV%252FWw%253D%253D%26SERVER%3DWZ6myaEXBLGliB%252BRW%252F74SA%253D%253D%26ORIGIN%3D941239582%26RD%3DRD&acw=&utt=; http://linkinghub.elsevier.com/retrieve/pii/S1526820912002595

Wang, Yihong; Sparano, Joseph A; Fineberg, Susan; Stead, Lesley; Sunkara, Jaya; Horwitz, Susan Band; McDaid, Hayley M

Elsevier BV

Medicine; Biochemistry, Genetics and Molecular Biology

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