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Role of Aflatoxin B1 as a risk for primary liver cancer in north Indian population

Clinical Biochemistry, ISSN: 0009-9120, Vol: 44, Issue: 14, Page: 1235-1240
2011
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Article Description

The present study was designed to determine whether aflatoxin B1 (AFB1) exposure has any role to play in hepatocellular carcinoma (HCC) patients from northern India. A total of 266 HCC patients and 251 patients of chronic liver disease without-HCC were enrolled into the study. All samples were screened for serological markers for hepatitis B and C infections and levels of AFB1 in food and urine samples. A threefold (OR = 3.43) and five-fold (OR = 5.47) increased risk of HCC was observed amongst HBV infection and AFB1-levels in food and urine samples, respectively. However, a non-significant risk was observed with respect to HCV infection (OR = 1.27) and alcohol consumption (OR = 1.18). A threefold (OR = 3.15) increased risk of HCC was observed amongst cases of non-viral etiology with respect to urinary AFB1. The data provides an exposure and disease risk information for establishing intervention studies to diminish the impact of aflatoxin exposure in Indian population.

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