Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity
Cell Metabolism, ISSN: 1550-4131, Vol: 24, Issue: 6, Page: 807-819
2016
- 608Citations
- 66Usage
- 774Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations608
- Citation Indexes607
- 607
- CrossRef412
- Patent Family Citations1
- Patent Families1
- Usage66
- Downloads63
- Abstract Views3
- Captures774
- Readers774
- 774
- Mentions1
- References1
- Wikipedia1
Article Description
Induction of trained immunity (innate immune memory) is mediated by activation of immune and metabolic pathways that result in epigenetic rewiring of cellular functional programs. Through network-level integration of transcriptomics and metabolomics data, we identify glycolysis, glutaminolysis, and the cholesterol synthesis pathway as indispensable for the induction of trained immunity by β-glucan in monocytes. Accumulation of fumarate, due to glutamine replenishment of the TCA cycle, integrates immune and metabolic circuits to induce monocyte epigenetic reprogramming by inhibiting KDM5 histone demethylases. Furthermore, fumarate itself induced an epigenetic program similar to β-glucan-induced trained immunity. In line with this, inhibition of glutaminolysis and cholesterol synthesis in mice reduced the induction of trained immunity by β-glucan. Identification of the metabolic pathways leading to induction of trained immunity contributes to our understanding of innate immune memory and opens new therapeutic avenues.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1550413116305393; http://dx.doi.org/10.1016/j.cmet.2016.10.008; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85003874481&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/27866838; https://linkinghub.elsevier.com/retrieve/pii/S1550413116305393; https://facultyopinions.com/prime/727004506#eval793541820; http://dx.doi.org/10.3410/f.727004506.793541820; https://dc.etsu.edu/etsu-works/15276; https://dc.etsu.edu/cgi/viewcontent.cgi?article=16542&context=etsu-works; https://dx.doi.org/10.1016/j.cmet.2016.10.008; http://linkinghub.elsevier.com/retrieve/pii/S1550413116305393
Elsevier BV
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