Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets
Cell Metabolism, ISSN: 1550-4131, Vol: 25, Issue: 3, Page: 686-697
2017
- 175Citations
- 200Captures
- 2Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations175
- Citation Indexes175
- 175
- CrossRef112
- Captures200
- Readers200
- 200
- Mentions2
- News Mentions2
- 2
Most Recent News
Discovery of a new metabolic pathway of a known lipid has implications in cancer, obesity
A collaborative Stony Brook University research team has discovered a novel metabolic pathway of the lipid ceramide, which is involved in cell death. The finding
Article Description
In an approach aimed at defining interacting partners of ceramide synthases (CerSs), we found that fatty acyl-CoA synthase ACSL5 interacts with all CerSs. We demonstrate that ACSL5-generated FA-CoA was utilized with de novo ceramide for the generation of acylceramides, poorly studied ceramide metabolites. Functionally, inhibition of ceramide channeling to acylceramide enhanced accumulation of de novo ceramide and resulted in augmentation of ceramide-mediated apoptosis. Mechanistically, we show that acylceramide generation is catalyzed by diacylglycerol acyltransferase 2 (DGAT2) on lipid droplets. In summary, this study identifies a metabolic pathway of acylceramide generation and its sequestration in LDs in cells and in livers of mice on a high-fat diet. The study also implicates this pathway in ceramide-mediated apoptosis, and has implications in co-regulation of triglyceride and sphingolipid metabolisms.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1550413117301006; http://dx.doi.org/10.1016/j.cmet.2017.02.010; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85014518061&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/28273483; https://linkinghub.elsevier.com/retrieve/pii/S1550413117301006; https://dx.doi.org/10.1016/j.cmet.2017.02.010
Elsevier BV
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