Modern optical microscopy methods to study biomolecular condensates
Current Opinion in Colloid & Interface Science, ISSN: 1359-0294, Vol: 52, Page: 101421
2021
- 9Citations
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Review Description
Cells achieve highly intricate internal organization via membrane-bound and membraneless organelles. Research over the past decade has implicated liquid–liquid phase separation, a phenomenon by which charged and often disordered biological macromolecules assemble into reversible liquid-like condensates, as the mechanism of formation of membraneless organelles in cells. During the same period, optical microscopy saw exciting advancements, including the super-resolution revolution, that were quickly adopted by researchers in the biological community. Today, there exists a vast library of techniques capable of providing unprecedented information regarding the formation, function, and dynamics of biomolecular condensates. In this review, we discuss a select number of modern optical microscopy methods that are particularly suited for studying biomolecular condensates both in vitro and in cells, as well as the associated technical challenges.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1359029421000054; http://dx.doi.org/10.1016/j.cocis.2021.101421; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85101326937&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S1359029421000054; https://dx.doi.org/10.1016/j.cocis.2021.101421
Elsevier BV
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