Allergen-specific pattern recognition receptor pathways
Current Opinion in Immunology, ISSN: 0952-7915, Vol: 22, Issue: 6, Page: 777-782
2010
- 64Citations
- 87Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations64
- Citation Indexes62
- 62
- CrossRef58
- Clinical Citations1
- PubMed Guidelines1
- Policy Citations1
- Policy Citation1
- Captures87
- Readers87
- 87
Review Description
Allergic diseases continue to plague modernized societies, underscoring the need to identify the molecular basis for the propensity of a small number of environmental proteins to provoke maladaptive, allergic responses. Recent data suggest that the ability of allergenic proteins to drive allergic responses in susceptible hosts is driven by their unique innate immune activating capabilities. Although the identification of allergen-specific pattern recognition receptors is in its infancy, studies to date have shown that allergens drive Th2-biased immune responses via directly engaging C-type lectin receptors (dectin-2, DC-SIGN, and mannose receptor) on dendritic cells and/or mimicking toll-like receptor 4 signaling complex molecules expressed on airway structural cells. Elucidation of the specific innate immune pathways activated by allergens holds great promise in defining new therapeutic targets for the treatment of allergic diseases.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0952791510001615; http://dx.doi.org/10.1016/j.coi.2010.10.011; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78649855748&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/21093238; https://linkinghub.elsevier.com/retrieve/pii/S0952791510001615; https://dx.doi.org/10.1016/j.coi.2010.10.011
Elsevier BV
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