LC3-associated phagocytosis: host defense and microbial response
Current Opinion in Immunology, ISSN: 0952-7915, Vol: 60, Page: 81-90
2019
- 50Citations
- 73Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations50
- Citation Indexes49
- CrossRef49
- 46
- Patent Family Citations1
- Patent Families1
- Captures73
- Readers73
- 73
Review Description
The innate immune system has evolved to recognize diverse microbes and destroy them. At the same time, microbial pathogens undermine immunity to cause disease. Here, we highlight recent advances in understanding an antimicrobial pathway called LC3-associated phagocytosis (LAP), which combines features of autophagy with phagocytosis. Upon phagocytosis, many microbes, including bacteria, fungi, and parasites, are sequestered in an LC3-positive, single-membrane bound compartment, a hallmark of LAP. LAP depends upon NADPH oxidase activity at the incipient phagosome and culminates in lysosomal trafficking and microbial degradation. Most often LAP is an effective host defense, but some pathogens evade LAP or replicate successfully in this microenvironment. Here, we review how LAP targets microbial pathogens and strategies pathogens employ to circumvent LAP.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0952791518301304; http://dx.doi.org/10.1016/j.coi.2019.04.012; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85067632767&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/31247378; https://linkinghub.elsevier.com/retrieve/pii/S0952791518301304; https://dx.doi.org/10.1016/j.coi.2019.04.012
Elsevier BV
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