Tissue-resident CD8 T cells in central nervous system inflammatory diseases: present at the crime scene and …guilty
Current Opinion in Immunology, ISSN: 0952-7915, Vol: 77, Page: 102211
2022
- 11Citations
- 32Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations11
- Citation Indexes11
- 11
- Captures32
- Readers32
- 32
Review Description
Tissue-resident memory T cells (T RM ) represent a subset of antigen-experienced T cells that are constantly retained in a given tissue with limited trafficking through the circulation. These cells are characterized by expression of molecules enabling their tissue anchoring and downregulation of molecules promoting tissue egress. They reside at sites of previous antigen encounter and their number increases with age. T RM have been shown to provide rapid and efficient protection against tissue reinfection and T RM density correlates with efficient antitumor responses. Intriguingly, the density of CD8 T RM is increased in the central nervous system (CNS) of patients with neuroinflammatory diseases such as multiple sclerosis, or suffering from neurodegenerative diseases. In this review, we discuss current knowledge regarding the diversity of CNS-resident CD8 T cells and their role in CNS autoimmunity. Given their likely contribution to the protracted course of several inflammatory diseases of the CNS, their therapeutic targeting becomes an important challenge.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0952791522000589; http://dx.doi.org/10.1016/j.coi.2022.102211; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85130740370&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/35644112; https://linkinghub.elsevier.com/retrieve/pii/S0952791522000589; https://dx.doi.org/10.1016/j.coi.2022.102211
Elsevier BV
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