Surface charge effect on mucoadhesion of chitosan based nanogels for local anti-colorectal cancer drug delivery
Colloids and Surfaces B: Biointerfaces, ISSN: 0927-7765, Vol: 128, Page: 439-447
2015
- 123Citations
- 118Captures
- 1Mentions
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations123
- Citation Indexes123
- 123
- CrossRef108
- Captures118
- Readers118
- 118
- Mentions1
- References1
- 1
Article Description
To develop more effective anticancer mucoadhesive drug delivery system for the treatment of colorectal cancer, chitosan based nanogels (NGs) were prepared by electrostatic interaction between chitosan (CS) and carboxymethyl-chitosan (CMCS). By respectively using tripolyphosphate (TPP) and CaCl 2 as ionic crosslinker, two well-characterized doxorubicin hydrochloride (DOX) loaded NGs with opposite zeta potential (DOX:CS/CMCS/TPP NGs, −32.6 ± 1.1 mV and DOX:CS/CMCS/Ca 2+ NGs, +31.8 ± 0.9 mV) were obtained. Compared with DOX:CS/CMCS/TPP NGs, DOX:CS/CMCS/Ca 2+ NGs were taken up to a greater extent by colorectal cancer cells, resulting in greater reduction in percentage of cell viability. Owing to high binding capability to mucin and inhibited paracellular transport by colon, DOX:CS/CMCS/Ca 2+ NGs exhibited improved mucoadhesion and limited permeability. This is beneficial to prolong the contact time of formulation onto intestinal mucosa and improved local drug concentration. The results provided evidence DOX:CS/CMCS/Ca 2+ NGs to be exciting and promising for the treatment of colorectal cancer.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0927776515001186; http://dx.doi.org/10.1016/j.colsurfb.2015.02.042; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84939967882&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/25769283; https://linkinghub.elsevier.com/retrieve/pii/S0927776515001186
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know