Quantitative comparison of different fluorescent dye-loaded nanoparticles
Colloids and Surfaces B: Biointerfaces, ISSN: 0927-7765, Vol: 206, Page: 111923
2021
- 6Citations
- 16Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations6
- Citation Indexes6
- CrossRef6
- Captures16
- Readers16
- 16
Article Description
Labeling nanoparticles with fluorescent dyes is a common approach to investigate their cell uptake and biodistribution, providing valuable information for the preclinical assessment of nanoparticles for drug delivery. However, the underlying assumption that the fluorescence intensity of dye-labeled nanoparticles correlates positively with the amount of nanoparticles taken up by cells might not be valid under some conditions, as it can be affected by many factors including dye dispersion, dye quenching, and material shading. Here we demonstrated that both nanoparticles with hydrophobic dyes encapsulated inside and nanoparticles with hydrophilic dyes conjugated on the particle surface suffer from different degrees of dye quenching, making it challenging for quantitative comparison of cell uptake of different nanoparticles. To address this challenge, we proposed a possible solution for direct comparative studies of dye-labeled nanoparticles. This work provides valuable information for designing and evaluating different nanoparticles for drug delivery applications.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0927776521003672; http://dx.doi.org/10.1016/j.colsurfb.2021.111923; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85108014674&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/34146992; https://linkinghub.elsevier.com/retrieve/pii/S0927776521003672; https://dx.doi.org/10.1016/j.colsurfb.2021.111923
Elsevier BV
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