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Chloramphenicol collagen sponges for local drug delivery in dentistry

Comptes Rendus Chimie, ISSN: 1631-0748, Vol: 18, Issue: 9, Page: 986-992
2015
  • 29
    Citations
  • 0
    Usage
  • 44
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    29
    • Citation Indexes
      29
  • Captures
    44

Article Description

Drug delivery systems based on natural drug carriers have become important due to their non-toxicity and biodegradability. We report here the synthesis and characterization of new biomaterials like sponges containing collagen, chloramphenicol and glutaraldehyde for dentistry. All sponges favour water absorption, showing that increasing the glutaraldehyde content leads to an increase in water uptake. The sponges showed resistance to collagenase degradation and strong activity against the tested bacteria. Kinetic data showed non-Fickian diffusion behaviour with a slow release rate. Taking into account that dental drug delivery systems exhibit low water absorption, slow drug release, high content of drug delivery, good antimicrobial activity, and resistance to enzymatic action, the results obtained in this study indicate the optimal content of glutaraldehyde for the sponge as being 0.5%. The properties of the designed formulations demonstrate that these sponges could be adequate for the treatment and/or the prophylaxis of infected lesions at the dental level.

Bibliographic Details

Graţiela Teodora Tihan; Camelia Ungureanu; Rãzvan Constantin Barbaresso; Roxana Gabriela Zgârian; Ileana Rău; Aurelia Meghea; Mãdãlina Georgiana Albu; Mihaela Violeta Ghica

Cellule MathDoc/Centre Mersenne

Chemistry; Chemical Engineering

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