Chloramphenicol collagen sponges for local drug delivery in dentistry
Comptes Rendus Chimie, ISSN: 1631-0748, Vol: 18, Issue: 9, Page: 986-992
2015
- 29Citations
- 44Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
Drug delivery systems based on natural drug carriers have become important due to their non-toxicity and biodegradability. We report here the synthesis and characterization of new biomaterials like sponges containing collagen, chloramphenicol and glutaraldehyde for dentistry. All sponges favour water absorption, showing that increasing the glutaraldehyde content leads to an increase in water uptake. The sponges showed resistance to collagenase degradation and strong activity against the tested bacteria. Kinetic data showed non-Fickian diffusion behaviour with a slow release rate. Taking into account that dental drug delivery systems exhibit low water absorption, slow drug release, high content of drug delivery, good antimicrobial activity, and resistance to enzymatic action, the results obtained in this study indicate the optimal content of glutaraldehyde for the sponge as being 0.5%. The properties of the designed formulations demonstrate that these sponges could be adequate for the treatment and/or the prophylaxis of infected lesions at the dental level.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1631074815001538; http://dx.doi.org/10.1016/j.crci.2015.06.004; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84941880589&origin=inward; https://comptes-rendus.academie-sciences.fr/chimie/articles/10.1016/j.crci.2015.06.004/; https://dx.doi.org/10.1016/j.crci.2015.06.004
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