Dopaminergic Modulation of Arousal in Drosophila
Current Biology, ISSN: 0960-9822, Vol: 15, Issue: 13, Page: 1165-1175
2005
- 306Citations
- 360Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations306
- Citation Indexes306
- CrossRef306
- 305
- Captures360
- Readers360
- 360
Article Description
Background: Arousal levels in the brain set thresholds for behavior, from simple to complex. The mechanistic underpinnings of the various phenomena comprising arousal, however, are still poorly understood. Drosophila behaviors have been studied that span different levels of arousal, from sleep to visual perception to psychostimulant responses. Results: We have investigated neurobiological mechanisms of arousal in the Drosophila brain by a combined behavioral, genetic, pharmacological, and electrophysiological approach. Administration of methamphetamine (METH) suppresses sleep and promotes active wakefulness, whereas an inhibitor of dopamine synthesis promotes sleep. METH affects courtship behavior by increasing sexual arousal while decreasing successful sexual performance. Electrophysiological recordings from the medial protocerebrum of wild-type flies showed that METH ingestion has rapid and detrimental effects on a brain response associated with perception of visual stimuli. Recordings in genetically manipulated animals show that dopaminergic transmission is required for these responses and that visual-processing deficits caused by attenuated dopaminergic transmission can be rescued by METH. Conclusions: We show that changes in dopamine levels differentially affect arousal for behaviors of varying complexity. Complex behaviors, such as visual perception, degenerate when dopamine levels are either too high or too low, in accordance with the inverted-U hypothesis of dopamine action in the mammalian brain. Simpler behaviors, such as sleep and locomotion, show graded responses that follow changes in dopamine level.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0960982205005142; http://dx.doi.org/10.1016/j.cub.2005.05.025; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=21844480910&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/16005288; https://linkinghub.elsevier.com/retrieve/pii/S0960982205005142; https://dx.doi.org/10.1016/j.cub.2005.05.025
Elsevier BV
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