EGO-1, a C. elegans RdRP, Modulates Gene Expression via Production of mRNA-Templated Short Antisense RNAs
Current Biology, ISSN: 0960-9822, Vol: 21, Issue: 6, Page: 449-459
2011
- 64Citations
- 127Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations64
- Citation Indexes64
- 64
- CrossRef54
- Captures127
- Readers127
- 127
Article Description
The development of the germline in Caenorhabditis elegans is a complex process involving the regulation of thousands of genes in a coordinated manner. Several genes required for small RNA biogenesis and function are among those required for the proper organization of the germline. EGO-1 is a putative RNA-directed RNA polymerase (RdRP) that is required for multiple aspects of C. elegans germline development and efficient RNA interference (RNAi) of germline-expressed genes. RdRPs have been proposed to act through a variety of mechanisms, including the posttranscriptional targeting of specific mRNAs, as well as through a direct interaction with chromatin. Despite extensive investigation, the molecular role of EGO-1 has remained enigmatic.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0960982211002107; http://dx.doi.org/10.1016/j.cub.2011.02.019; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79952818830&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/21396820; https://linkinghub.elsevier.com/retrieve/pii/S0960982211002107; http://www.cell.com/current-biology/abstract/S0960-9822(11)00210-7?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0960982211002107%3Fshowall%3Dtrue; http://linkinghub.elsevier.com/retrieve/pii/S0960982211002107; http://www.cell.com/article/S0960982211002107/abstract; http://www.cell.com/article/S0960982211002107/fulltext; http://www.cell.com/article/S0960982211002107/pdf; https://reader.elsevier.com/reader/sd/pii/S0960982211002107?token=734685F11EE29FE97A2EB97AB0A8AE3D78EEC3A8B82CBF79928D6B1F88CC1C6FC7CC9F1CDEC3637F9E5ED3C9D1A4BCB4&originRegion=eu-west-1&originCreation=20211008054045
Elsevier BV
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