Neuropoietin induces neuroepithelial cells to differentiate into astrocytes via activation of STAT3
Cytokine, ISSN: 1043-4666, Vol: 36, Issue: 1, Page: 17-22
2006
- 17Citations
- 22Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations17
- Citation Indexes16
- 16
- CrossRef12
- Patent Family Citations1
- 1
- Captures22
- Readers22
- 22
Article Description
Neuropoietin (NP) is a recently identified member of the interleukin (IL)-6 family of cytokines, which share glycoprotein 130 (gp130) as a signal-transducing receptor component, and is highly expressed in embryonic brain. In this study, we show that NP has the potential to induce neuroepithelial cells to differentiate into astrocytes. NP stimulation leads to promoter activation of the gene for an astrocyte marker, glial fibrillary acidic protein (GFAP), which is clearly inhibited by either expression of a dominant-negative form of a transcription factor, signal transducer and activator of transcription 3 (STAT3) or by a nucleotide-substitution in the STAT3-binding element within the gene promoter. We further show that NP induces binding of endogenous STAT3 to its cognate sequence within the gfap gene promoter in neuroepithelial cells. Moreover, like the other IL-6 cytokine family members, NP promotes astrocyte differentiation in a synergistic manner with bone-morphogenetic protein (BMP)-2. Taken together, our data indicate that NP can be considered as a new astrocyte-inducing cytokine in the developing brain.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1043466606002948; http://dx.doi.org/10.1016/j.cyto.2006.10.007; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33845994423&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/17161614; https://linkinghub.elsevier.com/retrieve/pii/S1043466606002948; https://dx.doi.org/10.1016/j.cyto.2006.10.007
Elsevier BV
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