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STATs as critical mediators of signal transduction and transcription: lessons learned from STAT5

Cytokine & Growth Factor Reviews, ISSN: 1359-6101, Vol: 15, Issue: 6, Page: 435-455
2004
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Review Description

Signal transducers and activators of transcription (Stats) comprise a family of seven transcription factors that are activated by a variety of cytokines, hormones and growth factors. Stats are activated through tyrosine phosphorylation, mainly by Jak kinases, that lead to their dimerization, nuclear translocation and regulation of target gene expression.

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